Calculate compounded tirzepatide (Mounjaro/Zepbound) reconstitution and weekly injection dose. The most effective GLP-1 for weight loss — up to 22.5% body weight reduction.
Tirzepatide follows a 5-step titration schedule. Each dose level is maintained for at least 4 weeks before increasing. Slower titration reduces side effects.
| Step | Weeks | Weekly Dose | Units (5mg/1mL, 100u) | Avg Weight Loss |
|---|---|---|---|---|
| Step 1 | 1-4 | 2,500 mcg (2.5mg) | 50 units | Starting dose |
| Step 2 | 5-8 | 5,000 mcg (5mg) | 100 units (full vial) | ~5% body weight |
| Step 3 | 9-12 | 7,500 mcg (7.5mg) | Use 10mg vial | ~10% body weight |
| Step 4 | 13-16 | 10,000 mcg (10mg) | Use 10mg vial | ~15% body weight |
| Step 5 | 17+ | 15,000 mcg (15mg) | Use 15mg vial | Up to 22.5% |
| Weekly Dose | Units (100u syringe) | mL to Draw | Weeks/Vial |
|---|---|---|---|
| 2,500 mcg (2.5mg) | 50 units | 0.50 mL | 2 weeks |
| 5,000 mcg (5mg) | 100 units | 1.00 mL | 1 week |
| Weekly Dose | Units (100u syringe) | mL to Draw | Weeks/Vial |
|---|---|---|---|
| 2,500 mcg | 50 units | 0.50 mL | 4 weeks |
| 5,000 mcg | 100 units | 1.00 mL | 2 weeks |
| 7,500 mcg | 75 units (use 1mL water) | 0.75 mL | ~1.3 weeks |
| 10,000 mcg | 100 units (use 1mL water) | 1.00 mL | 1 week |
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It was first approved as Mounjaro for type 2 diabetes and later as Zepbound for chronic weight management.
Inject subcutaneously once weekly on the same day each week. Recommended sites: abdomen, front of thighs, or upper arms. Rotate injection sites. Can be taken at any time, with or without meals.