What is the starting dose of semaglutide?

The standard starting dose is 250 mcg (0.25 mg) once weekly for 4 weeks. This allows your body to adjust and minimizes side effects like nausea.

How do I reconstitute compounded semaglutide?

Add the specified amount of bacteriostatic water to the lyophilized semaglutide vial. For a 3mg vial, adding 1.5mL gives 2,000 mcg/mL concentration. Inject water slowly down the vial wall, then gently swirl.

What is the maximum semaglutide dose?

The maximum recommended dose is 2,400 mcg (2.4 mg) once weekly for weight management (Wegovy), or 2,000 mcg (2.0 mg) for diabetes (Ozempic).

How long does semaglutide take to work?

Most people notice appetite suppression within the first 1-2 weeks. Significant weight loss typically becomes apparent after 4-8 weeks. Full effects are usually seen at 12-16 weeks on the maintenance dose.

How should semaglutide be stored?

Unreconstituted semaglutide can be stored at room temperature. Once reconstituted, refrigerate at 2-8°C and use within 28 days. Do not freeze reconstituted semaglutide.

What are the common side effects of semaglutide?

The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation. These typically improve over time and are minimized by following the proper titration schedule.

Weight Loss Peptide

Semaglutide Dosage Calculator

Calculate compounded semaglutide reconstitution and weekly injection dose. Includes titration schedule from 250 mcg to 2,400 mcg.

Calculator

Calculate your semaglutide dose

Semaglutide in vial (mg)

Bacteriostatic water (mL)

Weekly dose (mcg)

Syringe size

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Units to draw—

mL to draw—

Weeks per vial—

Visual syringe guide

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units to draw

Titration Schedule

Semaglutide dose escalation

Semaglutide requires a gradual dose increase (titration) to minimize gastrointestinal side effects. Never start at the full dose.

Phase	Weeks	Weekly Dose	Units (3mg/1.5mL, 100u)	Purpose
Month 1	1-4	250 mcg	12.5 units	Initiation — adjust to medication
Month 2	5-8	500 mcg	25 units	First escalation
Month 3	9-12	1,000 mcg	50 units	Therapeutic range begins
Month 4	13-16	1,700 mcg	85 units	Increased efficacy
Month 5+	17+	2,400 mcg	Use 5mg vial	Maximum dose (Wegovy)

Quick Reference: 3mg Vial + 1.5mL BAC Water

Weekly Dose	Units (100u syringe)	Units (50u syringe)	mL to Draw	Weeks/Vial
250 mcg	12.5 units	6.3 units	0.125 mL	12 weeks
500 mcg	25 units	12.5 units	0.25 mL	6 weeks
1,000 mcg	50 units	25 units	0.50 mL	3 weeks
1,700 mcg	85 units	42.5 units	0.85 mL	~1.7 weeks

Guide

How to use compounded semaglutide

Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes (Ozempic) and later approved for chronic weight management (Wegovy). Compounded semaglutide is a pharmacy-prepared version that requires reconstitution before use.

Step-by-Step Reconstitution

Step 1: Gather supplies — semaglutide vial, bacteriostatic water, insulin syringe (100-unit preferred), and alcohol swabs
Step 2: Clean both vial tops with alcohol swabs
Step 3: Draw 1.5mL of bacteriostatic water (for a 3mg vial) into the syringe
Step 4: Insert needle into semaglutide vial, inject water slowly down the inside wall
Step 5: Gently swirl until fully dissolved — solution should be clear and colorless
Step 6: Label the vial with reconstitution date
Step 7: Refrigerate at 2-8°C. Use within 28 days

Injection Instructions

Semaglutide is injected subcutaneously once per week, on the same day each week. Recommended injection sites: abdomen (2 inches from navel), front of thighs, or upper arms. Rotate injection sites each week. Inject at any time of day, with or without food.

Managing Side Effects

Nausea: Eat smaller meals, avoid fatty/fried foods, stay hydrated. Usually subsides within 2-3 weeks of each dose increase
Constipation: Increase fiber and water intake. Consider a stool softener if needed
Injection site reactions: Rotate sites, let alcohol dry completely before injecting
If side effects are severe: Stay at current dose for an extra 4 weeks before increasing. Consult your healthcare provider

Semaglutide vs Ozempic vs Wegovy

Ozempic and Wegovy are brand-name semaglutide products in pre-filled pens. Compounded semaglutide contains the same active ingredient but comes as lyophilized powder requiring reconstitution. The key difference is cost — compounded semaglutide is typically 60-80% less expensive than brand-name versions.

Important: Semaglutide is a prescription medication. This calculator is for educational purposes only. Always work with a licensed healthcare provider for proper dosing and medical supervision.

FAQ

Semaglutide frequently asked questions

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